{"id":15,"date":"2026-08-28T12:38:43","date_gmt":"2026-08-28T12:38:43","guid":{"rendered":"https:\/\/deliverbiotech.com\/portfoy\/"},"modified":"2026-10-26T10:46:26","modified_gmt":"2026-10-26T10:46:26","slug":"portfoy","status":"publish","type":"page","link":"https:\/\/deliverbiotech.com\/en\/portfoy\/","title":{"rendered":"Portfolio"},"content":{"rendered":"
\n
\"\"<\/figure>
\n
\n
\n

LNP Production<\/h3>\n\n\n\n

Our LNP formulations are produced with particle size, polydispersity, and encapsulation efficiency values that meet the quality thresholds in the literature, and are functionally validated in cell culture.<\/p>\n<\/div>\n\n\n\n

\n
Formulation<\/th>Z-Ave<\/strong>(nm)<\/th>PDI<\/th>Zeta potential (mV)<\/th><\/tr><\/thead>
LNP\/(Ref1)<\/td>74.73 \u00b1 3.17<\/td>0.149 \u00b1 0.005<\/td>+0.336 \u00b1 0.21<\/td><\/tr>
LNP\/(Ref2)<\/td>187.7 \u00b1 3.95<\/td>0.121 \u00b1 0.032<\/td>+0.264 \u00b1 0.26<\/td><\/tr>
LNP\/(Original) \u2013 mEGFP<\/td>136.0 \u00b1 3.66<\/td>0.193 \u00b1 0.053<\/td>\u22122.94 \u00b1 0.01<\/td><\/tr>
LNP\/(Original) \u2013 mFLuc<\/td>139.8 \u00b1 0.10<\/td>0.051 \u00b1 0.033<\/td>\u22122.90 \u00b1 0.10<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

Measurements were performed using dynamic and electrophoretic light scattering at an mRNA concentration of 0.1 \u00b5g\/mL, with n = 3 replicates.<\/p>\n\n\n\n

\n
Explore Services<\/a><\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/section>\n\n\n\n
\n
\n

Analysis and Characterization<\/h2>\n\n\n\n

The developed LNP formulations are evaluated in terms of critical quality characteristics such as particle size, polydispersity index (PDI), zeta potential, and encapsulation efficiency. The results are interpreted according to the formulation composition, production conditions, and application requirements. Representative analysis results are presented along with relevant measurement conditions and repeatability information.<\/p>\n<\/div>\n\n\n\n

\n
\n
\"\"<\/figure>\n\n\n\n
\n
\n

Analysis of encapsulation efficacy with Ribogreen.<\/h3>\n\n\n\n

<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\n
\"\"<\/figure>\n\n\n\n
\n
\n

Analysis of reporter gene-mediated in vivo transfection efficacy.<\/h3>\n\n\n\n

<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n

\n
Critical Quality Characteristic<\/th>Obtained Value<\/th>Target Range<\/th><\/tr><\/thead>
Encapsulation Efficiency (%)<\/td>%94,7 \u00b1 2,7<\/td>\u2265 %90<\/td><\/tr>
Z-Ave (nm)<\/td>74.7\u2013187.7 nm<\/td>60\u2013200 nm<\/td><\/tr>
PDI<\/td>0,121\u20130,149<\/td>\u2264 0.25<\/td><\/tr>
Zeta Potential (mV)<\/td>+0.26 to +0.34 mV<\/td>-10 to +10 mV<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n
\n
\n

Production in accordance with quality criteria<\/h3>\n\n\n\n

<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n\n\n\n

\n
\n

Our Other Services<\/h2>\n\n\n\n

Our customers and partners can benefit from the following innovative solutions.<\/p>\n<\/div>\n\n\n\n

\n
\n
\n
\n

mRNA Production<\/h3>\n\n\n\n

IVT template preparation involves the synthesis of mRNA via T7 in vitro transcription, cap addition, and poly(A) tailing, followed by N1-methyl-pseudo-UTP modification. After purification, the concentration and integrity of the resulting mRNA are measured, and the dsRNA ratio is determined.<\/p>\n<\/div>\n<\/div>\n<\/div>

\"\"<\/figure><\/div>\n\n\n\n
\"\"<\/figure>
\n
\n
\n

Support for Projects Submitted to Institutions<\/h3>\n\n\n\n

We supply custom-made LNP, mRNA, and sgRNA for projects you plan to carry out for institutions such as T\u00dcB\u0130TAK and T\u00dcSEB.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n

\n
\n
\n

Consulting for Pharmaceutical Companies<\/h3>\n\n\n\n

Leveraging our academic expertise and experience, we provide consulting services to pharmaceutical companies in areas such as licensing, R&D, project writing, and project execution.<\/p>\n\n\n\n

.<\/p>\n<\/div>\n<\/div>\n<\/div>

\"\"<\/figure><\/div>\n\n\n\n
\"\"<\/figure>
\n
\n
\n

Customized Solutions for Innovative Projects<\/h3>\n\n\n\n

Target organ and tissue selective LNP production for in vivo CAR-T therapy and the design and production of mRNA, saRNA, circRNA and plasmid constructs.<\/p>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n

\n
Explore More<\/a><\/div>\n<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"

LNP \u00dcretimi LNP form\u00fclasyonlar\u0131m\u0131z, literat\u00fcrdeki kalite e\u015fiklerini kar\u015f\u0131layan partik\u00fcl boyutu, polidispersite ve enkaps\u00fclasyon etkinli\u011fi de\u011ferleriyle \u00fcretilmekte ve h\u00fccre k\u00fclt\u00fcr\u00fcnde i\u015flevsel olarak do\u011frulanmaktad\u0131r.r. Formulation Z-Ave(nm) PDI Zeta potential (mV) LNP\/(Ref1) 74,73 \u00b1 3,17 0,149 \u00b1 0,005 +0,336 \u00b1 0,21 LNP\/(Ref2) 187,7 \u00b1 3,95 0,121 \u00b1 0,032 +0,264 \u00b1 0,26 LNP\/(Orj) \u2013 mEGFP 136,0 \u00b1 3,66 0,193 […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"page-with-title","meta":{"_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-15","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/pages\/15","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/comments?post=15"}],"version-history":[{"count":299,"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/pages\/15\/revisions"}],"predecessor-version":[{"id":1223,"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/pages\/15\/revisions\/1223"}],"wp:attachment":[{"href":"https:\/\/deliverbiotech.com\/en\/wp-json\/wp\/v2\/media?parent=15"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}